5'-O-Tritylthymidine

5'-O-Tritylthymidine is an inhibitor of TK-2 and inhibits angiogenesis[1]. 5'-O-Tritylthymidine targets FAK-Mdm-2 interactions, decreasing cell viability and increasing apoptosis.

Product Specifications

CAS Number

[7791-71-1]

Product Name Alternative

5-OTT

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis

Type

Biochemical Assay Reagents

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/5-o-tritylthymidine.html

Purity

99.79

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(N=C(O)C(C)=C1)N1[C@@H]2O[C@H](COC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)[C@@H](O)C2

Molecular Formula

C29H28N2O5

Molecular Weight

484.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Hernández A et al. Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase. J Med Chem. 2002 Sep 12;45 (19) :4254-63. |[2]Golubovskaya V et al. A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo. Anticancer Agents Med Chem. 2013 May;13 (4) :532-45.