5'-O-Tritylthymidine
5'-O-Tritylthymidine is an inhibitor of TK-2 and inhibits angiogenesis[1]. 5'-O-Tritylthymidine targets FAK-Mdm-2 interactions, decreasing cell viability and increasing apoptosis.
Product Specifications
CAS Number
7791-71-1
Product Name Alternative
5-OTT
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Biochemical Assay Reagents
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5-o-tritylthymidine.html
Purity
99.79
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N=C(O)C(C)=C1)N1[C@@H]2O[C@H](COC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)[C@@H](O)C2
Molecular Formula
C29H28N2O5
Molecular Weight
484.54
Precautions
H302, H315, H319, H335
References & Citations
[1]Hernández A et al. Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase. J Med Chem. 2002 Sep 12;45 (19) :4254-63. |[2]Golubovskaya V et al. A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo. Anticancer Agents Med Chem. 2013 May;13 (4) :532-45.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Available Sizes
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