Rauwolscine
Rauwolscine is a selective α2-adrenoceptor antagonist that inhibits tumor growth and induces apoptosis[1].
Product Specifications
CAS Number
131-03-3
Product Name Alternative
α-Yohimbine; Corynanthidine; Isoyohimbine
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Natural Products
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rauwolscine.html
Purity
98.27
Solubility
H2O : 2.24 mg/mL (ultrasonic; warming)
Smiles
[H][C@@]12[C@](CC[C@@H]([C@H]2C(OC)=O)O)(CN(CCC3=C4NC5=CC=CC=C53)[C@]4(C1)[H])[H]
Molecular Formula
C21H26N2O3
Molecular Weight
354.44
References & Citations
[1]A Bruzzone, et al. Alpha2-adrenoceptor action on cell proliferation and mammary tumour growth in mice. Br J Pharmacol. 2008 Oct;155 (4) :494-504.|[2]S La Marca, et al. The alpha-2 antagonists idazoxan and rauwolscine but not yohimbine or piperoxan are anxiolytic in the Vogel lick-shock conflict paradigm following intravenous administration. Life Sci. 1994;54 (10) :PL179-84.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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