Rauwolscine

Rauwolscine is a selective α2-adrenoceptor antagonist that inhibits tumor growth and induces apoptosis[1].

Product Specifications

CAS Number

[131-03-3]

Product Name Alternative

α-Yohimbine; Corynanthidine; Isoyohimbine

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rauwolscine.html

Purity

98.27

Solubility

H2O : 2.24 mg/mL (ultrasonic; warming)

Smiles

[H][C@@]12[C@](CC[C@@H]([C@H]2C(OC)=O)O)(CN(CCC3=C4NC5=CC=CC=C53)[C@]4(C1)[H])[H]

Molecular Formula

C21H26N2O3

Molecular Weight

354.44

References & Citations

[1]A Bruzzone, et al. Alpha2-adrenoceptor action on cell proliferation and mammary tumour growth in mice. Br J Pharmacol. 2008 Oct;155 (4) :494-504.|[2]S La Marca, et al. The alpha-2 antagonists idazoxan and rauwolscine but not yohimbine or piperoxan are anxiolytic in the Vogel lick-shock conflict paradigm following intravenous administration. Life Sci. 1994;54 (10) :PL179-84.