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GPX4-IN-9

GPX4-IN-9 (Compound A16) is a glutathione peroxidase 4 (GPX4) inhibitor that specifically targets GPX4 under both in vitro and in vivo conditions, inducing ferroptosis. GPX4-IN-9 exhibits cytotoxicity against pancreatic cancer cells and can be used in cancer research[1].

Product Specifications

CAS Number

3032746-99-6

UNSPSC

12352005

Target

Ferroptosis; Glutathione Peroxidase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gpx4-in-9.html

Purity

99.18

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=S(C(C=C1)=CC=C1CN(C2=CC=C(C=C2)C3=NC4=C(S3)C=CC=C4)CC#C)(N(C#C)C)=O

Molecular Formula

C26H21N3O2S2

Molecular Weight

471.59

References & Citations

[1]Tang Z, et al. Novel Covalent Probe Selectively Targeting Glutathione Peroxidase 4 In Vivo: Potential Applications in PancrTang Z, et al. Novel Covalent Probe Selectively Targeting Glutathione Peroxidase 4 In Vivo: Potential Applications in Pancreatic Cancer Therapy. J Med Chem. 2024 Feb 8;67 (3) :1872-1887.eatic Cancer Therapy. J Med Chem. 2024 Feb 8;67 (3) :1872-1887.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

GPX4

Available Sizes

Frequently Asked Questions

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