MenA-IN-2
MenA-IN-2 (Compound 11) is an inhibitor of 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA) . MenA-IN-2 inhibits MenA with an IC50 value of 22 µM and inhibits Mycobacterium tuberculosis (Mtb) with an GIC50 value of 10 µM. MenA-IN-2 can curb the continuous transmission of Mtb[1].
Product Specifications
CAS Number
3026690-49-0
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mena-in-2.html
Purity
99.84
Solubility
DMSO : 250 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CCCN(C1=CC=C(C=C1)CN2CCC(CC2)COC3=CC=C(C=C3)Cl)C
Molecular Formula
C23H31ClN2O
Molecular Weight
386.96
References & Citations
[1]Berg K, et al. SAR study of piperidine derivatives as inhibitors of 1,4-dihydroxy-2-naphthoate isoprenyltransferase (MenA) from Mycobacterium tuberculosis. Eur J Med Chem. 2023 Jan 18;249:115125.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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