Taniborbactam (hydrochloride)

Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam hydrochloride has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria[1][2].

Product Specifications

CAS Number

[2244235-49-0]

Product Name Alternative

VNRX-5133 (hydrochloride)

UNSPSC

12352005

Target

Bacterial; Beta-lactamase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/taniborbactam-hydrochloride.html

Purity

99.97

Solubility

DMSO : 200 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)

Smiles

OC(C1=C(OB(O)[C@@H](NC(C[C@@H]2CC[C@@H](NCCN)CC2)=O)C3)C3=CC=C1)=O.[H]Cl.[H]Cl

Molecular Formula

C19H30BCl2N3O5

Molecular Weight

462.18

References & Citations

[1]Liu B , et al. Discovery of Taniborbactam (VNRX-5133) : A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. J Med Chem. 2019 Dec 16.|[2]Krajnc A, et al. Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases. J Med Chem. 2019 Sep 26;62 (18) :8544-8556.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Citation 01

Antimicrob Agents Chemother. 2022 Feb 15;66 (2) :e0167621.|Antimicrob Agents Chemother. 2025 Jun 9:e0029725.|Antimicrob Agents Chemother. 2023 Jul 18;67 (7) :e0033923.|Antimicrob Agents Chemother. 2024 Feb 7;68 (2) :e0133223.|Antimicrob Agents Chemother. 2024 Nov 6;68 (11) :e0077524.|Engineering. 2024 Apr 12.|FEMS Microbiol Lett. 2025 Jan 10:372:fnaf044.|Int J Antimicrob Agents. 2024 Jan;63 (1) :107030.|Int J Antimicrob Agents. 2025 Jun 20:107557.|J Antimicrob Chemother. 2023 May 3;78 (5) :1191-1194.|J Glob Antimicrob Resist. 2025 Jul 7:44:265-271.|Sci Rep. 2025 Sep 29;15 (1) :33616.