INE963
INE963 is a potent and fast-acting blood-stage antimalarial agent, with an EC50s of 3-6 nM. INE963 is potential for single-dose cures in uncomplicated malaria[1].
Product Specifications
CAS Number
2640567-43-5
UNSPSC
12352005
Target
FLT3; Haspin Kinase; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ine963.html
Purity
99.58
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1(CCN(CC1)C2=NN3C(S2)=NC=C3C4=C(OC)N=C(C(C)C)C=C4)CN
Molecular Formula
C19H26N6O2S
Molecular Weight
402.51
References & Citations
[1]Taft BR, et, al. Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria. J Med Chem. 2022 Mar 10;65 (5) :3798-3813.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Plasmodium
Available Sizes
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