INE963

INE963 is a potent and fast-acting blood-stage antimalarial agent, with an EC50s of 3-6 nM. INE963 is potential for single-dose cures in uncomplicated malaria[1].

Product Specifications

CAS Number

[2640567-43-5]

UNSPSC

12352005

Target

FLT3; Haspin Kinase; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ine963.html

Purity

99.58

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1(CCN(CC1)C2=NN3C(S2)=NC=C3C4=C(OC)N=C(C(C)C)C=C4)CN

Molecular Formula

C19H26N6O2S

Molecular Weight

402.51

References & Citations

[1]Taft BR, et, al. Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria. J Med Chem. 2022 Mar 10;65 (5) :3798-3813.