MK-6892
MK-6892 is a potent, selective, and full agonist for the high affinity nicotinic acid (NA) receptor GPR109A. Ki and GTPγS EC50 of MK-6892 on the Human GPR109A is 4 nM and 16 nM, respectively.
Product Specifications
CAS Number
917910-45-3
UNSPSC
12352005
Target
GPR109A
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MK-6892.html
Purity
99.43
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC(C=C1)=CN=C1C2=NOC(CC(C)(C)C(NC3=C(C(O)=O)CCCC3)=O)=N2
Molecular Formula
C19H22N4O5
Molecular Weight
386.40
References & Citations
[1]Shen HC, et al. Discovery of a biaryl cyclohexene carboxylic acid (MK-6892) : a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. J Med Chem. 2010 Mar 25;53 (6) :2666-70.|[2]Kim HY, et al. Discovery of 4- (phenyl) thio-1H-pyrazole derivatives as agonists of GPR109A, a high affinity niacin receptor. Arch Pharm Res. 2015 Jun;38 (6) :1019-32.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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