NEDD4L rabbit pAb
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012],
Product Specifications
Background
Synonyms
E3 ubiquitin-protein ligase NEDD4-like (EC 6.3.2.-) (NEDD4.2) (Nedd4-2)
Gene ID
23327
UniProt
Q96PU5
Cellular Locus
Cytoplasm. Golgi apparatus. Endosome, multivesicular body. May be recruited to exosomes by NDFIP1.
Host
Rabbit
Species Reactivity
Human,Mouse
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human NEDD4L AA range: 28-78
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB
Validated Applications
WB
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
WB 1:500-2000
Molecular Weight
110-120kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES14528-1.pdf
Observed Molecular Weight
110 - 120 kD
Subcellular Location
Cytoplasm . Golgi apparatus . Endosome, multivesicular body . May be recruited to exosomes by NDFIP1.
Other Product Names
E3 ubiquitin-protein ligase NEDD4-like (EC 6.3.2.-) (NEDD4.2) (Nedd4-2)
Gene ID (Human)
23327
SwissProt (Human)
Q96PU5
Available Sizes
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