Brinazarone
Product Specifications
UNSPSC Description
Brinazarone (SR 33287) is an inhibitor for acid lysosomal sphingomyelinase, and leads to cellular lipidosis. Brinazarone potentiates the cytotoxic effects of anti-Thy 1.2 AT15E RTA-IT on T2 cells and anti-CD5 T101 on CEM cells[1].
Target Antigen
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brinazarone.html
Smiles
O=C(C1=C(C(C)C)C=C2C=CC=CN21)C3=CC=C(C=C3)OCCCNC(C)(C)C
Molecular Weight
392.53
References & Citations
[1]Jaffrézou JP, et al., In vitro and in vivo enhancement of ricin-A chain immunotoxin activity by novel indolizine calcium channel blockers: delayed intracellular degradation linked to lipidosis induction. Cancer Res. 1992 Mar 1;52(5):1352-9.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-106611/Brinazarone-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-106611/
Clinical Information
No Development Reported
CAS Number
89622-90-2
Curated Selection
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