Brinazarone

Brinazarone (SR 33287) is an inhibitor for acid lysosomal sphingomyelinase, and leads to cellular lipidosis. Brinazarone potentiates the cytotoxic effects of anti-Thy 1.2 AT15E RTA-IT on T2 cells and anti-CD5 T101 on CEM cells[1].

Product Specifications

CAS Number

[89622-90-2]

Product Name Alternative

SR 33287

UNSPSC

12352005

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/brinazarone.html

Smiles

O=C(C1=C(C(C)C)C=C2C=CC=CN21)C3=CC=C(C=C3)OCCCNC(C)(C)C

Molecular Formula

C25H32N2O2

Molecular Weight

392.53

References & Citations

[1]Jaffrézou JP, et al., In vitro and in vivo enhancement of ricin-A chain immunotoxin activity by novel indolizine calcium channel blockers: delayed intracellular degradation linked to lipidosis induction. Cancer Res. 1992 Mar 1;52 (5) :1352-9.