EGFR/ACK1-IN-1
EGFR T790M/L858R/ACK1-IN-1 is a dual inhibitor of EGFR T790M/L858R and ACK1. IC50 values are 23 and 263 nM, respectively. EGFR T790M/L858R/ACK1-IN-1 can inhibit cell proliferation and has antitumor activity[1].
Product Specifications
UNSPSC
12352005
Target
Ack1; EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-t790m-l858r-ack1-in-1.html
Purity
98.19
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(C2=C1)N=C(N=C2NC3=CC=CC(NC(C=C)=O)=C3)NC4=CN(N=C4)CC
Molecular Formula
C22H20ClN7O
Molecular Weight
433.89
References & Citations
[1]Wang A, et al. Design, Synthesis, and Biological Evaluation of Dual Inhibitors of EGFRL858R/T790M/ACK1 to Overcome Osimertinib Resistance in Nonsmall Cell Lung Cancers. J Med Chem. 2024 Feb 22;67 (4) :2777-2801.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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