EGFR/ACK1-IN-1

EGFR T790M/L858R/ACK1-IN-1 is a dual inhibitor of EGFR T790M/L858R and ACK1. IC50 values are 23 and 263 nM, respectively. EGFR T790M/L858R/ACK1-IN-1 can inhibit cell proliferation and has antitumor activity[1].

Product Specifications

UNSPSC

12352005

Target

Ack1; EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-t790m-l858r-ack1-in-1.html

Purity

98.19

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C(C2=C1)N=C(N=C2NC3=CC=CC(NC(C=C)=O)=C3)NC4=CN(N=C4)CC

Molecular Formula

C22H20ClN7O

Molecular Weight

433.89

References & Citations

[1]Wang A, et al. Design, Synthesis, and Biological Evaluation of Dual Inhibitors of EGFRL858R/T790M/ACK1 to Overcome Osimertinib Resistance in Nonsmall Cell Lung Cancers. J Med Chem. 2024 Feb 22;67 (4) :2777-2801.