Mequitazine

Mequitazine is a potent, and long-acting histamine H1 antagonist.

Product Specifications

CAS Number

[29216-28-2]

Product Name Alternative

LM-209

UNSPSC

12352005

Hazard Statement

H301

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Mequitazine.html

Purity

99.99

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C12=CC=CC=C1N(CC3CN4CCC3CC4)C5=C(C=CC=C5)S2

Molecular Formula

C20H22N2S

Molecular Weight

322.47

Precautions

H301

References & Citations

[1]Gonnot V, et al. Expedient synthesis of mequitazine an antihistaminic drug by palladium catalyzed allylic alkylation of sodium phenothiazinate. Chem Pharm Bull (Tokyo) . 2009 Nov;57 (11) :1300-2.|[2]El-Nakeeb MA, et a. In vitro antibacterial activity of some antihistaminics belonging to different groups against multi-drug resistant clinical isolates. Braz J Microbiol. 2011 Jul;42 (3) :980-91.|[3]Martinez-Mir I, et al. Antihistaminic and anticholinergic activities of mequitazine in comparison with clemizole. J Pharm Pharmacol. 1988 Sep;40 (9) :655-6.|[4]Satake N, et al. Possible mechanisms of vasoinhibitory effects of mequitazine, an antiallergic agent, on the contractions of isolated rat aorta induced by K+, phenylephrine, 5-hydroxytryptamine, and Ca2+. J Cardiovasc Pharmacol. 1994 Apr;23 (4) :669-73.