SC-VC-PAB-MMAE
SC-VC-PAB-MMAE (NHS-VC-PAB-MMAE) is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker SC-VC-PAB[1].
Product Specifications
CAS Number
2259318-46-0
Product Name Alternative
NHS-VC-PAB-MMAE
UNSPSC
12352203
Hazard Statement
H300+H330, H340, H360, H370, H372, H412
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sc-vc-pab-mmae.html
Purity
99.29
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
Molecular Formula
C68H105N11O17
Molecular Weight
1348.62
Precautions
H300+H330, H340, H360, H370, H372, H412
References & Citations
[1]Brian Lannutti, et al. Ror1 antibody immunoconjugates. WO2018237335A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Auristatin
Available Sizes
Frequently Asked Questions
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