YGsy2p-IN-H23
YGsy2p-IN-H23 is a potent and first-in-class inhibitor for yeast glycogen synthase 2 (yGsy2p) with an IC50 of 875 μM for human glycogen synthase 1 (hGYS1) . yGsy2p-IN-H23 bounds within the uridine diphosphate glucose binding pocket of yGsy2p. yGsy2p-IN-H23 is used for the research of glycogen storage diseases (GSDs) [1].
Product Specifications
CAS Number
[1269190-98-8]
UNSPSC
12352005
Target
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ygsy2p-in-h-23.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C2=C(C3=CC=CC=C3)N=CN2CCC4N(C)CCC4)C=C1OC
Molecular Formula
C23H27N3O2
Molecular Weight
377.48
References & Citations
[1]Buyun Tang, et al. Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. J Med Chem. 2020 Apr 9;63 (7) :3538-3551.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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