JD-5037
JD-5037 is a potent CB1R antagonist with an IC50 of 1.5 nM.
Product Specifications
CAS Number
[1392116-14-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cannabinoid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/JD-5037.html
Concentration
10mM
Purity
99.38
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
NC([C@H](C(C)C)/N=C(NS(=O)(C1=CC=C(Cl)C=C1)=O)\N2N=C(C3=CC=C(Cl)C=C3)[C@@H](C4=CC=CC=C4)C2)=O
Molecular Formula
C27H27Cl2N5O3S
Molecular Weight
572.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Chorvat RJ. Peripherally restricted CB1 receptor blockers. Bioorg Med Chem Lett. 2013 Sep 1;23 (17) :4751-60.|[2]Knani I, et al. Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader-Willi syndrome. Mol Metab. 2016 Oct 22;5 (12) :1187-1199.|[3]Mukhopadhyay B, et al. Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms. Hepatology. 2015 May;61 (5) :1615-26.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CB1
Available Sizes
Curated Selection
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