Tropisetron
Tropisetron is an orally active 5-HT3R antagonist (Ki = 5.3 nM) as well as being a potent and selective α7 nicotinic partial agonist (EC50 = 1.3 μM) . Tropisetron prevents phosphorylation and activation of the p38 MAPK. Tropisetron inhibits both IL-2 gene transcription and IL-2 synthesis in stimulated T cells. Tropisetron inhibits the binding to DNA and the transcriptional activity of NFAT and AP-1. Tropisetron is anti-inflammatory and antiemetic. Tropisetron has antitumor and neuroprotective effects. Tropisetron can be studied in research for diseases including hemorrhagic cystitis, chronic joint inflammation, lung cancer and chronic cerebral hypoperfusion[1][2][3][4][5][6].
Product Specifications
CAS Number
89565-68-4
Product Name Alternative
SDZ-ICS-930 (free base)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor; AP-1; JAK; nAChR; NF-κB; Nuclear Factor of activated T Cells (NFAT) ; p38 MAPK
Type
Reference compound
Related Pathways
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tropisetron.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CNC2=C1C=CC=C2)O[C@H]3C[C@H]4CC[C@H](N4C)C3
Molecular Formula
C17H20N2O2
Molecular Weight
284.36
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Lactoferrin
Citation 01
Available Sizes
Frequently Asked Questions
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