Propargyl-PEG5-amine
Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG5-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
[1589522-46-2]
UNSPSC
12352203
Hazard Statement
H302, H312, H332
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/propargyl-peg5-amine.html
Purity
99.35
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C#CCOCCOCCOCCOCCOCCN
Molecular Formula
C13H25NO5
Molecular Weight
275.34
Precautions
H302, H312, H332
References & Citations
[1]Robert Zamboni, et al. Raf-degrading conjugate compounds. WO2018200981A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker; PEG Linkers
Available Sizes
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