Bisindolylmaleimide VIII (acetate)
Product Specifications
Product Name Alternative
Ro 31-7549 (acetate); Bis VIII (acetate)
UNSPSC Description
Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII acetate has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively[1]. Bisindolylmaleimide VIII acetate facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases[2].
Target Antigen
Apoptosis; PKC
Type
Reference compound
Related Pathways
Apoptosis;Epigenetics;TGF-beta/Smad
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bisindolylmaleimide-viii-acetate.html
Purity
99.68
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C(C1=CN(CCCN)C2=C1C=CC=C2)=C3C4=CN(C)C5=C4C=CC=C5)NC3=O.CC(O)=O
Molecular Weight
458.51
References & Citations
[1]Wilkinson SE, et al. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J. 1993 Sep 1;294 ( Pt 2):335-7.|[2]Ohtsuka T, et al. Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways. J Biol Chem. 2002 Aug 9;277(32):29294-303.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-129624A/Bisindolylmaleimide-VIII-acetate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-129624A/Bisindolylmaleimide-VIII-acetate-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
138516-31-1
Available Sizes
Curated Selection
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