PKR-IN-C51

PKR-IN-C51 (compound 51) is an ATP-competitive double-stranded RNA-activated protein kinase (PKR) inhibitor with an IC50 of 9 μM. PKR-IN-C51 inhibits intracellular PKR activation in a dose-dependent manner in primary mouse macrophages[1].

Product Specifications

CAS Number

[1314594-23-4]

Product Name Alternative

U31930,Methophenazine (diethanesulfonate),2'3'-didehydro-2'3'-dideoxyadenosine,Methophenazine

UNSPSC

12352005

Target

Ser/Thr Protease

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pkr-in-c51.html

Purity

99.79

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(NC1=C2C=CC=C1)=C2C3=NC(NCCC4=CNC5=C4C=CC=C5)=NC=C3

Molecular Formula

C23H21N5

Molecular Weight

367.45

References & Citations

[1]Ruslana Bryk, et al. Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett. 2011 Jul 1;21 (13) :4108-14.