WAY-262611
WAY-262611 is a Wnt/β-Catenin agonist that increases bone formation rate with an EC50 of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also a Dkk1 inhibitor[1].
Product Specifications
CAS Number
[1123231-07-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Wnt; β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/WAY-262611.html
Purity
99.96
Solubility
DMSO : ≥ 42 mg/mL
Smiles
NCC1CCN(C2=NC=CC(C3=CC=C4C=CC=CC4=C3)=N2)CC1
Molecular Formula
C20H22N4
Molecular Weight
318.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Pelletier JC, et al. (1- (4- (Naphthalen-2-yl) pyrimidin-2-yl) piperidin-4-yl) methanamine: a wingless beta-catenin agonist that increases bone formation rate. J Med Chem. 2009 Nov 26;52 (22) :6962-5.|[2]L Enochson, et al. GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition. Osteoarthritis Cartilage. 2014 Apr;22 (4) :566-77.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6178698-01 0.1 mL
CARHSP1 (Calcium Regulated Heat Stable Protein 1, 24kD, CRHSP-24, CSDC1, MGC111446) (FITC)
Ask
View Details 
MBS6178698-02 5x 0.1 mL
CARHSP1 (Calcium Regulated Heat Stable Protein 1, 24kD, CRHSP-24, CSDC1, MGC111446) (FITC)
Ask
View Details