Jagged-1 (188-204)

Jagged-1 (188-204) is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells[1][2][3].

Product Specifications

CAS Number

[219127-21-6]

UNSPSC

12352209

Target

Notch

Type

Peptides

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/jagged-1-188-204.html

Purity

99.72

Solubility

H2O : 3.33 mg/mL (ultrasonic)

Smiles

OC(C=C1)=CC=C1C[C@H](NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)NC([C@H](CC(O)=O)NC([C@@H](N)CS)=O)=O)=O)CC2=CC=C(C=C2)O)=O)CC3=CC=C(C=C3)O)=O)C(NCC(N[C@@H](CC4=CC=CC=C4)C(NCC(N[C@@H](CS)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CS)C(N[C@@H](CCCNC(N)=N)C(N6[C@@H](CCC6)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C93H127N25O26S3

Molecular Weight

2107.40

References & Citations

[1]Jundt F, et al. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells. Blood. 2004 May 1;103 (9) :3511-5.|[2]Weijzen S, et al. The Notch ligand Jagged-1 is able to induce maturation of monocyte-derived human dendriticcells. J Immunol. 2002 Oct 15;169 (8) :4273-8.|[3]Nickoloff BJ, et al. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ. 2002 Aug;9 (8) :842-55.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Citation 01

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