EMI56

EMI56, the derivative of EMI1, displays greater potency toward mutant EGFR than EMI1. EMI56 inhibits EGFR triple mutants[1].

Product Specifications

CAS Number

2414374-41-5

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/emi56.html

Concentration

10mM

Purity

99.72

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCN(CC)C1=C(C)C=C2C(OC(C(C3=NC(C=CC=C4)=C4O3)=C2)=O)=C1

Molecular Formula

C21H20N2O3

Molecular Weight

348.40

References & Citations

[1]Punit Saraon, et al. A Drug Discovery Platform to Identify Compounds That Inhibit EGFR Triple Mutants.Nat Chem Biol. 2020 May;16 (5) :577-586.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

EGFR/ErbB1/HER1

Available Sizes

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