α-Hydroxyglutaric acid (disodium)

α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1].

Product Specifications

CAS Number

[40951-21-1]

Product Name Alternative

2-Hydroxyglutarate (disodium) ; 2-Hydroxyglutaric acid (disodium) ; 2-Hydroxypentanedioic acid (disodium)

UNSPSC

12352211

Hazard Statement

H302, H312, H332

Target

Endogenous Metabolite; Histone Demethylase

Type

Natural Products

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/α-hydroxyglutaric-acid-disodium.html

Purity

98.0

Solubility

H2O : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O[Na])C(O)CCC(O[Na])=O

Molecular Formula

C5H6Na2O5

Molecular Weight

192.08

Precautions

H302, H312, H332

References & Citations

[1]Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19 (1) :17-30.