Hydrocortisone hemisuccinate (hydrate)

Hydrocortisone hemisuccinate hydrate (Hydrocortisone 21-hemisuccinate hydrate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate hydrate inhibits the bioactivity of IL-6 and IL-3 with IC50 values of 6.7 and 21.4 μM, respectively. Hydrocortisone hemisuccinate hydrate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers[1][2][3].

Product Specifications

CAS Number

[83784-20-7]

Product Name Alternative

Hydrocortisone 21-hemisuccinate (hydrate)

UNSPSC

12352211

Hazard Statement

H315, H319

Target

Interleukin Related

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hydrocortisone-hemisuccinate-hydrate.html

Purity

96.42

Smiles

C[C@@]12[C@](CC[C@]2(O)C(COC(CCC(O)=O)=O)=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])[C@H](C1)O.O

Molecular Formula

C25H36O9

Molecular Weight

480.55

Precautions

H315, H319

References & Citations

[1]Kang BS, et, al. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biol Pharm Bull. 2001 Jun;24 (6) :701-3.|[2]You YC, et, al. In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy. Carbohydr Polym. 2015 Oct 5;130:243-53.|[3]Langhoff E, et, al. The immunosuppressive potency in vitro of physiological and synthetic steroids on lymphocyte cultures. Int J Immunopharmacol. 1987;9 (4) :469-73.