Axinelline A
Axinelline A is a potent COX inhibitor with IC50s of 2.22 μM and 8.89 μM against COX-2 and COX-1, respectively. Axinelline A shows anti-inflammatory activity[1].
Product Specifications
CAS Number
[1593741-99-1]
UNSPSC
12352005
Target
COX
Type
Natural Products
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/axinelline-a.html
Solubility
10 mM in DMSO
Smiles
CCOC([C@H](CO)NC(C1=C(C(O)=CC=C1)O)=O)=O
Molecular Formula
C12H15NO6
Molecular Weight
269.25
References & Citations
[1]Ju Z, et al. Synthesis and Anti-Inflammatory Activity of the Natural Cyclooxygenase-2 Inhibitor Axinelline A and Its Analogues. J Nat Prod. 2023 Apr 28;86 (4) :958-965.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-1; COX-2
Curated Selection
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