Itacnosertib (hydrochloride)
Itacnosertib hydrochloride (TP-0184 hydrochloride) is the inhibitor for FLT3, ACVR1 (ALK2, IC50=8 nM) and JAK2 (IC50=8540 nM) . Itacnosertib hydrochloride exhibits anti-leukemic activity[1][2].
Product Specifications
CAS Number
2409543-84-4
Product Name Alternative
TP-0184 (hydrochloride)
UNSPSC
12352005
Target
Akt; Anaplastic lymphoma kinase (ALK) ; FLT3; JAK; mTOR; PI3K; STAT; TGF-beta/Smad; TGF-β Receptor
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/itacnosertib-hydrocholide.html
Concentration
10mM
Purity
99.43
Solubility
DMSO : 5.56 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CN1CCN(C2=CC=C(NC3=NC=CC(NC4=CC=CN=C4C5=NC=CC=C5)=N3)C=C2OC)CC1.[H]Cl
Molecular Formula
C26H29ClN8O
Molecular Weight
505.01
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
ALK2; JAK2
Available Sizes
Frequently Asked Questions
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