Cnicin
Product Specifications
UNSPSC Description
Cnicin is an orally bioavailable sesquiterpene lactone. Cnicin has antibacterial and antiproliferative properties and induces apoptosis in primary myeloma cells. Cnicin also exhibits activity against SARS-CoV-2. Cnicin inhibits the viral replication of SARS CoV-2 with an IC50 of 1.18 μg/mL. Cnicin can promote functional nerve regeneration[1][2][3][4][5].
Target Antigen
Apoptosis; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection;Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cnicin.html
Smiles
O=C(C([C@@H](O)CO)=C)O[C@@H](C/C(C)=C/CC1)[C@](C2=C)([H])[C@@](OC2=O)([H])/C=C1\CO
Molecular Weight
378.42
References & Citations
[1]Jöhrer K, et al. Antimyeloma activity of the sesquiterpene lactone cnicin: impact on Pim-2 kinase as a novel therapeutic target. J Mol Med (Berl). 2012 Jun;90(6):681-93.|[2]Alhadrami HA, et al. Cnicin as an Anti-SARS-CoV-2: An Integrated In Silico and In Vitro Approach for the Rapid Identification of Potential COVID-19 Therapeutics. Antibiotics (Basel). 2021 May 7;10(5):542.|[3]Philipp Gobrecht, et al. Cnicin promotes functional nerve regeneration. Phytomedicine. 2024 Jul:129:155641.|[4]Sura Baykan Erel, et al. Secondary metabolites of Centaurea calolepis and evaluation of cnicin for anti-inflammatory, antioxidant, and cytotoxic activities. Pharm Biol. 2011 Aug;49(8):840-9. |[5]Sandra M Bach, et al. Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin. Nat Prod Commun. 2011 Feb;6(2):163-6.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-137984/Cnicin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-137984/Cnicin-SDS-MedChemExpress.pdf
CAS Number
24394-09-0
Available Sizes
Curated Selection
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