Cnicin

Cnicin is an orally bioavailable sesquiterpene lactone. Cnicin has antibacterial and antiproliferative properties and induces apoptosis in primary myeloma cells. Cnicin also exhibits activity against SARS-CoV-2. Cnicin inhibits the viral replication of SARS CoV-2 with an IC50 of 1.18 μg/mL. Cnicin can promote functional nerve regeneration[1][2][3][4][5].

Product Specifications

CAS Number

[24394-09-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cnicin.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C([C@@H](O)CO)=C)O[C@@H](C/C(C)=C/CC1)[C@](C2=C)([H])[C@@](OC2=O)([H])/C=C1\CO

Molecular Formula

C20H26O7

Molecular Weight

378.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Jöhrer K, et al. Antimyeloma activity of the sesquiterpene lactone cnicin: impact on Pim-2 kinase as a novel therapeutic target. J Mol Med (Berl) . 2012 Jun;90 (6) :681-93.|[2]Alhadrami HA, et al. Cnicin as an Anti-SARS-CoV-2: An Integrated In Silico and In Vitro Approach for the Rapid Identification of Potential COVID-19 Therapeutics. Antibiotics (Basel) . 2021 May 7;10 (5) :542.|[3]Philipp Gobrecht, et al. Cnicin promotes functional nerve regeneration. Phytomedicine. 2024 Jul:129:155641.|[4]Sura Baykan Erel, et al. Secondary metabolites of Centaurea calolepis and evaluation of cnicin for anti-inflammatory, antioxidant, and cytotoxic activities. Pharm Biol. 2011 Aug;49 (8) :840-9. |[5]Sandra M Bach, et al. Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin. Nat Prod Commun. 2011 Feb;6 (2) :163-6.