GW311616
Product Specifications
UNSPSC Description
GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC50 value of 22 nM and Ki value of 0.31 nM[1].
Target Antigen
Elastase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/GW311616.html
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
O=C1[C@@H](C(C)C)[C@@](N(C(/C=C/CN2CCCCC2)=O)CC3)([H])[C@]3([H])N1S(=O)(C)=O
Molecular Weight
397.53
References & Citations
[1]Ohbayashi H,et al. Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80.|[2]Jiang KL, et al. Neutrophil elastase and its therapeutic effect on leukemia cells. Mol Med Rep. 2015 Sep;12(3):4165-4172.|[3]Macdonald SJ, et al. The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate. Bioorg Med Chem Lett. 2001 Apr 9;11(7):895-8.Adv Sci (Weinh). 2023 Jun 22;e2302613.|Cell Immunol. 2020 Jun;352:104101.|EMBO Rep. 2023 Aug 31;e57032.|J Leukoc Biol. 2022 Aug 19.|Life Sci. 2020 Feb 1;242:117229.|Sci Rep. 2017 Nov 30;7(1):16628.|Int Immunopharmacol. 2022 Dec 7;114:109537.|J Invest Dermatol. 2020 Jul;140(7):1371-1378.e3.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15891/GW311616-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15891/GW311616-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
198062-54-3
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
