N-Succinimidyl-S-acetylthioacetate

N-Succinimidyl S-acetylthioacetate (SATA) is a protein modifying agent. N-Succinimidyl S-acetylthioacetate adds sulfhydryl groups to proteins and other amine-containing molecules in a protected form. N-Succinimidyl-S-acetylthioacetate can thiolate antibodies, thereby promoting efficient attachment of antibodies to other molecules and exerting conjugation activity. N-Succinimidyl-S-acetylthioacetate can be used in immunoassays such as ELISA studies[1][2][3].

Product Specifications

CAS Number

[76931-93-6]

Product Name Alternative

SATA

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/n-succinimidyl-s-acetylthioacetate.html

Purity

99.56

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(ON1C(CCC1=O)=O)CSC(C)=O

Molecular Formula

C8H9NO5S

Molecular Weight

231.23

Precautions

H302, H315, H319, H335

References & Citations

[1]J.L.M.Heeremans, et al. Interference of ϵ-amino-caproic acid with [N-succinimidyl S-acetylthioacetate derived] thiol-introduction into glu-plasminogen. Volume 8, Supplement 2, 1994, Pages 138-141.|[2]Allen KJH, et al. Evaluation of N-Succinimidyl S-Acetylthioacetate Ligand for Radiolabeling of HumanizedAntibodies with 188Rhenium. Cancer Biother Radiopharm. 2018 Oct;33 (8) :349-355.|[3]Nanda S, et al. Thermostable alpha-amylase conjugated antibodies as probes for immunodetection in ELISA. J Immunoassay Immunochem. 2002;23 (3) :327-45.