Pelitrexol
Pelitrexol (AG 2037) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), a purine biosynthetic enzyme. Pelitrexol also inhibits mTORC1 by reducing GTP-bound Rheb level, a mTORC1 obligate activator. Pelitrexol shows robust tumor growth suppression in mice[1].
Product Specifications
CAS Number
446022-33-9
Product Name Alternative
AG 2037
UNSPSC
12352005
Target
Antifolate
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AG_2037.html
Concentration
10mM
Purity
98.07
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(O)CC[C@@H](C(O)=O)NC(C1=CC(C)=C(CC[C@H](CN2)CC3=C2N=C(N)NC3=O)S1)=O
Molecular Formula
C20H25N5O6S
Molecular Weight
463.51
References & Citations
[1]Emmanuel N, et al. Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase. Cell Rep. 2017 Jun 27;19 (13) :2665-2680.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Goat FSH (Follicle Stimulating Hormone) ELISA Kit
Goat FSH (Follicle Stimulating Hormone) ELISA Kit
Goat FSH (Follicle Stimulating Hormone) ELISA Kit
Goat FSH (Follicle Stimulating Hormone) ELISA Kit
Recombinant Pasteurella haemolytica Leukotoxin (lktA), partial