Atuzabrutinib
Atuzabrutinib (SAR 444727) is a potent, selective reversible inhibitor of Btk (Bruton's tyrosine kinase) inhibitor. Atuzabrutinib inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling[1].
Product Specifications
CAS Number
[1581714-49-9]
Product Name Alternative
SAR 444727; PRN473
UNSPSC
12352005
Hazard Statement
H315-H319
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/atuzabrutinib.html
Purity
98.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=C2C(N([C@H]3CN(CCC3)C(/C(C#N)=C/C(C)(C)C)=O)N=C2C4=C(C=C(C=C4)OC5=CC=CC=C5)F)=NC=N1
Molecular Formula
C30H30FN7O2
Molecular Weight
539.60
Precautions
P264-P280-P302+P352-P305+P351+P338-P362+P364
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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