AD80

AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.

Product Specifications

CAS Number

[1384071-99-1]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Raf; RET; Ribosomal S6 Kinase (RSK) ; Src

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AD80.html

Purity

99.88

Solubility

DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=CC(C(F)(F)F)=CC=C1F)NC2=CC=C(C3=NN(C(C)C)C4=NC=NC(N)=C43)C=C2

Molecular Formula

C22H19F4N7O

Molecular Weight

473.43

Precautions

H302, H312, H332

References & Citations

[1]Dar AC, et al. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology.Nature. 2012 Jun 6;486 (7401) :80-4.|[2]Liu H, et al. Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia.Cell Rep. 2017 Feb 28;18 (9) :2088-2095.