5-Aminosalicylic Acid-d3 (hydrochloride)
Product Specifications
UNSPSC Description
5-Aminosalicylic Acid-d3 (hydrochloride) is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) hydrochloride acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.
Target Antigen
Endogenous Metabolite; Isotope-Labeled Compounds; NF-κB; PAK; PPAR
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton;Metabolic Enzyme/Protease;NF-κB;Others;Vitamin D Related/Nuclear Receptor
Field of Research
Inflammation/Immunology; Cancer
Solubility
10 mM in DMSO
Smiles
OC(C1=C(C([2H])=C([2H])C(N)=C1[2H])O)=O.Cl
Molecular Weight
192.61
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Dammann K, et al. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2349-60.;Fang HM, et al. 5-aminosalicylic acid in combination with Nimesulide inhibits proliferation of colon carcinoma cells in vitro. World J Gastroenterol. 2007 May 28;13(20):2872-7.;Rousseaux C, et al. The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ. Carcinogenesis. 2013 Nov;34(11):2580-6.
Shipping Conditions
Blue Ice
Clinical Information
No Development Reported
CAS Number
1346601-18-0
Available Sizes
Curated Selection
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