5-Aminosalicylic Acid-d3 (hydrochloride)

5-Aminosalicylic Acid-d3 (hydrochloride) is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) hydrochloride acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.

Product Specifications

CAS Number

[1346601-18-0]

Product Name Alternative

Mesalamine-D3 (hydrochloride) ; 5-ASA-D3 (hydrochloride) ; Mesalazine-D3 (hydrochloride)

UNSPSC

12352005

Target

Endogenous Metabolite; Isotope-Labeled Compounds; NF-κB; PAK; PPAR

Type

Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease; NF-κB; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Inflammation/Immunology; Cancer

Purity

99.00

Solubility

10 mM in DMSO

Smiles

OC(C1=C(C([2H])=C([2H])C(N)=C1[2H])O)=O.Cl

Molecular Formula

C7H5D3ClNO3

Molecular Weight

192.61

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Dammann K, et al. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015 Oct;1853 (10 Pt A) :2349-60.; Fang HM, et al. 5-aminosalicylic acid in combination with Nimesulide inhibits proliferation of colon carcinoma cells in vitro. World J Gastroenterol. 2007 May 28;13 (20) :2872-7.; Rousseaux C, et al. The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ. Carcinogenesis. 2013 Nov;34 (11) :2580-6.