NSC 185058
Product Specifications
UNSPSC Description
NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. Inhibition of ATG4B using NSC 185058 markedly attenuates autophagic activity[1].
Target Antigen
Atg4; Autophagy
Type
Reference compound
Related Pathways
Autophagy
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NSC_185058.html
Purity
99.46
Solubility
DMSO : ≥ 125 mg/mL
Smiles
S=C(C1=NC=CC=C1)NC2=NC=CC=C2
Molecular Weight
215.27
References & Citations
[1]Huang T, et al. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell. 2017 Dec 11;32(6):840-855.e8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-125169/NSC-185058-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-125169/NSC-185058-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
39122-38-8
Available Sizes
Curated Selection
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