H-Ile-Lys-Val-Ala-Val-OH
Product Specifications
UNSPSC Description
H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways[1][2].
Target Antigen
Akt; ERK
Type
Peptides
Related Pathways
MAPK/ERK Pathway;PI3K/Akt/mTOR;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/h-ile-lys-val-ala-val-oh.html
Purity
99.42
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
CC(C)[C@@H](C(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@@H](N)[C@@H](C)CC)=O)=O)=O)=O
Molecular Weight
528.69
References & Citations
[1]Nomizu M, et al. The all-D-configuration segment containing the IKVAV sequence of laminin A chain has similar activities to the all-L-peptide in vitro and in vivo. J Biol Chem. 1992 Jul 15;267(20):14118-21.|[2]Li B, et al. IKVAV regulates ERK1/2 and Akt signalling pathways in BMMSC population growth and proliferation. Cell Prolif. 2014 Apr;47(2):133-45.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P4322/H-Ile-Lys-Val-Ala-Val-OH-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P4322/H-Ile-Lys-Val-Ala-Val-OH-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
131167-89-0
Available Sizes
Curated Selection
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