H-Ile-Lys-Val-Ala-Val-OH

H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways[1][2].

Product Specifications

CAS Number

[131167-89-0]

UNSPSC

12352209

Target

Akt; ERK

Type

Peptides

Related Pathways

MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/h-ile-lys-val-ala-val-oh.html

Purity

99.42

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

CC(C)[C@@H](C(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@@H](N)[C@@H](C)CC)=O)=O)=O)=O

Molecular Formula

C25H48N6O6

Molecular Weight

528.69

References & Citations

[1]Nomizu M, et al. The all-D-configuration segment containing the IKVAV sequence of laminin A chain has similar activities to the all-L-peptide in vitro and in vivo. J Biol Chem. 1992 Jul 15;267 (20) :14118-21.|[2]Li B, et al. IKVAV regulates ERK1/2 and Akt signalling pathways in BMMSC population growth and proliferation. Cell Prolif. 2014 Apr;47 (2) :133-45.