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JAK-IN-10

JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders[1]. JAK-IN-10 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

916741-98-5

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Benzenesulfonamide,_5-[[5-fluoro-4-[[4-_2-propyn-1-yloxy_phenyl]amino]-2-pyrimidinyl]amino]-2-methyl-.html

Concentration

10mM

Purity

99.72

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=S(C1=CC(NC2=NC=C(F)C(NC3=CC=C(OCC#C)C=C3)=N2)=CC=C1C)(N)=O

Molecular Formula

C20H18FN5O3S

Molecular Weight

427.45

Precautions

H302, H315, H319

References & Citations

[1]Hong Ren, et al. Composition for ophthalmic administration.US20140206708A1.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

JAK

Available Sizes

Frequently Asked Questions

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