(RS) -4C3HPG

(RS) -4C3HPG (4-Carboxy-3-hydroxyphenylglycine) is an effective competitive antagonist at the metabotropic glutamate receptor 1 (mGluR1) in the central nervous system, and it is also an agonist at mGluR2/3. (RS) -4C3HPG exhibits neuroprotective effects in an acute global ischemia rat model[1][2].

Product Specifications

CAS Number

[134052-66-7]

Product Name Alternative

4-Carboxy-3-hydroxyphenylglycine

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rs-4c3hpg.html

Smiles

O=C(O)C(N)C1=CC=C(C(O)=O)C(O)=C1

Molecular Formula

C9H9NO5

Molecular Weight

211.17

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Gerber U, et al. 4C3HPG (RS-4-carboxy-3-hydroxyphenylglycine), a weak agonist at metabotropic glutamate receptors, occludes the action of trans-ACPD in hippocampus. Eur J Pharmacol. 1992 Oct 20;221 (2-3) :401-2. |[2]Henrich-Noack P, et al. The mGlu receptor ligand (S) -4C3HPG protects neurons after global ischaemia in gerbils. Neuroreport. 1998 Apr 20;9 (6) :985-8.