TTNPB
Product Specifications
UNSPSC Description
TTNPB is a highly potent RAR agonist. Competitive binding assays using human RARs yield IC50s of α=5.1 nM, β= 4.5 nM, and γ=9.3 nM, respectively.
Target Antigen
Apoptosis; Autophagy; RAR/RXR
Type
Reference compound
Related Pathways
Apoptosis;Autophagy;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/TTNPB.html
Solubility
DMSO : 7.58 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=C(/C=C(C2=CC=C3C(C)(C)CCC(C)(C)C3=C2)\C)C=C1
Molecular Weight
348.48
References & Citations
[1]Pignatello MA, et al. Multiple factors contribute to the toxicity of the aromatic retinoid, TTNPB (Ro 13-7410): binding affinities and disposition. Toxicol Appl Pharmacol. 1997 Feb;142(2):319-27.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15682/TTNPB-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15682/TTNPB-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
71441-28-6
Available Sizes
Curated Selection
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