TTNPB
TTNPB is a highly potent RAR agonist. Competitive binding assays using human RARs yield IC50s of α=5.1 nM, β= 4.5 nM, and γ=9.3 nM, respectively.
Product Specifications
CAS Number
71441-28-6
Product Name Alternative
Ro 13-7410; Arotinoid acid; AGN191183
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H360
Target
Apoptosis; Autophagy; RAR/RXR
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/TTNPB.html
Purity
99.85
Solubility
DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)C1=CC=C(/C=C(C2=CC=C3C(C)(C)CCC(C)(C)C3=C2)\C)C=C1
Molecular Formula
C24H28O2
Molecular Weight
348.48
Precautions
H315, H319, H335, H360
References & Citations
[1]Pignatello MA, et al. Multiple factors contribute to the toxicity of the aromatic retinoid, TTNPB (Ro 13-7410) : binding affinities and disposition. Toxicol Appl Pharmacol. 1997 Feb;142 (2) :319-27.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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