C8-Ceramide

C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro[1][2][3][4].

Product Specifications

CAS Number

[74713-59-0]

Product Name Alternative

N-Octanoyl-D-erythro-sphingosine

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H332, H335

Target

Apoptosis; Autophagy; PKC

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Epigenetics; TGF-beta/Smad

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/c8-ceramide.html

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CCCCCCCC(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)=O

Molecular Formula

C26H51NO3

Molecular Weight

425.69

Precautions

H302, H315, H319, H332, H335

References & Citations

[1]Rebeca López-Marure , et al. Ceramide promotes the death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis. Biochem Biophys Res Commun. 2002 May 10;293 (3) :1028-36.|[2]Curtis J. Pritzl, et al. A ceramide analogue stimulates dendritic cells to promote T cell responses upon virus infections. J Immunol. 2015 May 1; 194 (9) : 4339-4349.|[3]Yuli C. Chang, et al. Exogenous C8-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells. Int J Mol Sci. 2018 Oct; 19 (10) : 3010.|[4]H W Huang, et al. Ceramides modulate protein kinase C activity and perturb the structure of Phosphatidylcholine/Phosphatidylserine bilayers. Biophys J. 1999 Sep; 77 (3) : 1489-1497.|[5]Lan Weiss, et al. Ceramide contributes to pathogenesis and may be targeted for therapy in VCP inclusion body myopathy. Hum Mol Genet. 2021 Jan 7; ddaa248.