FDW028
FDW028 a potent and highly selective FUT8 inhibitor. FUT8 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the chaperone-mediated autophagy (CMA) pathway. FDW028 can be used for metastatic colorectal cancer (mCRC) research[1].
Product Specifications
CAS Number
2768426-49-7
UNSPSC
12352005
Target
Akt; Autophagy; mTOR
Type
Reference compound
Related Pathways
Autophagy; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fdw028.html
Purity
99.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC(CNCC2=CC=CC=C2)=NC3=NC(NCC4=CC=C(CC)C=C4)=NN31
Molecular Formula
C22H24N6O
Molecular Weight
388.47
References & Citations
[1]Wang M, et al. FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer. Cell Death Dis. 2023 Aug 3;14 (8) :495.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LY433268 100 µg
DMT1 (SLC11A2) (NM_001174130) Human Over-expression Lysate
Sign In for Pricing
View Details 
BNUM1486-50 1x 50 µL
DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1486), 1mg/mL
Sign In for Pricing
View Details ![APC Anti-Mouse CD73 Antibody[TY/23]](https://cdn.genprice.uk/products/763/68dd14a6061270361e7d1c39/imageurl/e-ab-f1089e.webp)