NA-014
NA-014 (40) is a selective EAAT2 positive allosteric modulator (PAM), with an EC50 of 3 nM[1].
Product Specifications
UNSPSC
12352005
Target
EAAT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/na-014.html
Purity
99.49
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NCCC1=CC=C(F)C=C1)C(C2=CC=C(C#N)C=C2)N3CCN(C)CC3
Molecular Formula
C22H25FN4O
Molecular Weight
380.46
References & Citations
[1]Andréia C K Fontana, et al. Synthesis and Structure-Activity Relationships for Glutamate Transporter Allosteric Modulators. J Med Chem. 2024 Apr 25;67 (8) :6119-6143.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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