WNTinib
Product Specifications
UNSPSC Description
WNTinib (APS-8-100-2) is a multi-kinase inhibitor that selectively antagonizes β-catenin (CTNNB1) mutated hepatocellular carcinoma (HCC). WNTinib downregulates oncogenicWntsignaling by inhibiting KIT/MAPK and downstream EZH2 activation[1].
Target Antigen
Apoptosis; Wnt
Type
Reference compound
Related Pathways
Apoptosis;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wntinib.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(C=C1F)OC2=CC(C(NC)=O)=NC=C2)NC3=CC=C(C(F)(C(F)(F)F)F)C=C3
Molecular Weight
498.38
References & Citations
[1]Rialdi A, et al. WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma. Nat Cancer. 2023 Aug;4(8):1157-1175.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-160765/WNTinib-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-160765/WNTinib-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2770091-44-4
Available Sizes
Curated Selection
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