TRFS-green

TRFS-green is a highly selective off−on fluorescent probe for imaging selenoprotein thioredoxin reductase (TrxR) in living cells. TRFS-green has the maximum absorbance at around 373 nm. After it is activated by TrxR, the maximum absorbance shifts to around 440 nm[1].

Product Specifications

CAS Number

[1513848-14-0]

UNSPSC

12352005

Target

TrxR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/trfs-green.html

Concentration

10mM

Purity

97.0

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(OC1CSSC1)NC2=CC=C(C3=C4C=CC=C32)C(N(CCCC)C4=O)=O

Molecular Formula

C20H20N2O4S2

Molecular Weight

416.51

References & Citations

[1]Liangwei Zhang, et al. Highly selective off-on fluorescent probe for imaging thioredoxin reductase in living cells. J Am Chem Soc. 2014 Jan 8;136 (1) :226-33.|[2]Xinming Li, et al. A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage. Nat Commun. 2019 Jun 21;10 (1) :2745.