Levomefolate (calcium)

Levomefolate calcium is an orally active, BBB-penetrable and active form of folic acid. Levomefolate calcium can be used as a food supplement for folic acid and in the research of neural tube defect diseases[1][2][3][4].

Product Specifications

CAS Number

[151533-22-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antifolate

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Levomefolate-calcium.html

Purity

99.46

Solubility

H2O : 4.4 mg/mL (ultrasonic; warming)

Smiles

O=C([O-])CC[C@@H](C([O-])=O)NC(C1=CC=C(NC[C@@H]2N(C)C3=C(N=C(N)NC3=O)NC2)C=C1)=O.[Ca+2]

Molecular Formula

C20H23CaN7O6

Molecular Weight

497.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Wiesinger H, Eydeler U, Richard F, et al. Bioequivalence evaluation of a folate-supplemented oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium versus ethinylestradiol/drospirenone and levomefolate calcium alone. Clin Drug Investig. 2012 Oct 1;32 (10) :673-84.|[2]Hartmut Blodea, Christine Klippingb, Frank Richardc, et al. Bioequivalence study of an oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium relative to ethinylestradiol/drospirenone and to levomefolate calcium alone. Contraception.2012, 85 (2), :177-184|[3]Rapkin RB, Creinin MD. The combined oral contraceptive pill containing drospirenone and ethinyl estradiol plus levomefolate calcium. Expert Opin Pharmacother. 2011 Oct;12 (15) :2403-10. doi: 10.1517/14656566.2011.610791.|[4]Levomefolic_acid